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They compete with histamine for histamine receptor type 1 (H1) receptor sites in the blood vessels, GI tract, and respiratory tract, which, in turn, inhibits physiologic effects that histamine normally induces at the H1 receptor sites.Regular use of an intranasal steroid spray may be more appropriate for patients with chronic symptoms.Daily use of an antihistamine, decongestant, or both can be considered either instead of or in addition to nasal steroids.In addition to this antihistamine effect, they can have parallel pharmacological properties, for example antimuscarinic and adrenolytic effects which must be considered.It is usual to classify H1-antihistamines into two classes: old ones, called first-generation agents, which are sedating and recent ones, called second-generation agents which have slight or no sedating effects because they do not cross the blood-brain barrier.




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